Supplementation with probiotics has many mechanisms of action that bene t health, including but not limited to: (1) supporting metabolic activity, such as the production of short-chain fatty acids and vitamins, nutrient absorption, and digestion of lactose; (2) adhering to intestinal epithelial cells to help maintain a healthy balance of organisms in the intestinal tract; (3) helping to establish populations of good bacteria after disruption in balance; (4) supporting immune function; (5) promoting intestinal epithelial cell survival; (6) supporting healthy bowel function; and (7) degrading oxalates.
Common challenges associated with probiotic supplementation are maintaining stability of the organisms during distribution and shelf life and, once taken by a consumer, survival of the organisms as they travel through the digestive tract so that they reach the target tissue (intestines) alive. To help ensure stability, NUTRAHARMONY packages the ProbioFlora 30DF capsules in sealed, nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics, such as heat, moisture, and oxygen. Careful selection of organisms is another way NUTRAHARMONY helps ensure stability. Careful organism selection, as performed for ProbioFlora 30DF, is also a critical aspect of supporting digestive survival. To further support resistance to low pH and the delivery of microorganisms to the small intestines, NUTRAHARMONY employs DRcapsTM gastro-resistant capsules. These specially designed, innovative capsules help slow exposure of actives to stomach acid to promote a more targeted release.
HOWARUTM (Bi dobacterium lactis HN019) Discovered in 1899, B lactis play a key role in the human micro ora throughout a person’s life. Researchers have identi ed strain HN019 as having excellent probiotic potential based upon its ability to survive the transit through the human gastrointestinal tract, adhere to epithelial cells, and proliferate. B lactis HN019 has been extensively studied, and its safety and effectiveness is well accepted.[7,8] To assess the impact of Bi dobacterium lactis HN019 supplementation on whole-gut transit time in adults, 30 subjects were given daily doses for 14 days of 17.2 billion colony-forming units (CFU), 1.8 billion CFU, or placebo. Decreases in mean whole-gut transit time over the 14-day study period were statistically signi cant in the high-dose group and the low-dose group, but not in the placebo group. This level of dosing also supported other parameters of healthy GI function, as were self-reported by patient survey.  In another study of preschool-age children, supplementing milk for one year with 1.9 x 10 CFU per day B lactis HN019 and 2.4 g/day of prebiotic oligosaccharides supported both healthy iron status and weight gain. In a randomized, double-blind, placebo-controlled human dietary intervention study in elderly subjects (>60 yrs.), supplementary B lactis HN019 resulted in statistically signi cant increases in the bene cial organisms bi dobacteria and lactobacilli.
Lactobacillus acidophilus (Lactobacillus acidophilus La-14) This common inhabitant of the human mouth, intestinal tract, and vagina, is also found in some traditional fermented milks (e.g., ke r) and is widely used in probiotic foods and supplements. It has a history of safe human consumption. The L acidophilus La-14 strain is of human origin and has been identi ed as a type A1 L acidophilus. L acidophilus shows excellent adhesion to human epithelial cell-lines.
Lactobacillus plantarum (Lactobacillus plantarum Lp-115) This bacteria was isolated from plant material and is abundantly present in lactic acid-fermented foods, such as olives and sauerkraut. In vitro studies have shown that L plantarum strain Lp-115 has excellent adhesion to epithelial cell lines. In addition, L plantarum is resistant to low pH conditions and survives the presence of bile at duodenal concentrations.
Bi dobacterium longum (Bi dobacterium longum Bl-05) The B longum Bl-05 strain is well accepted as safe for human consumption. B longum is resistant to low pH and bile salts and is well suited to the intestinal environment.
Take one capsule with water daily, or as directed by your healthcare practitioner.
Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner.
Does Not Contain
Wheat, gluten, soy, animal or dairy products, sh, shell sh, peanuts, tree nuts, egg, ingredients derived from genetically modi ed organisms (GMOs), arti cial colors, arti cial sweeteners, or arti cial preservatives